Effects of Xuezhikang (Red Yeast Rice) on Blood lipids, Hemorheology and the Expression of P65 and Tissue Factor in Atherosclerotic Rats

Source:
By:yabing yang, meilin liu

DOI: https://doi.org/10.30564/jams.v2i1.318

Abstract:

Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezhikang (red yeast rice). Methods: 32 Wistar rats were randomly divided into normal control group, Xuezhikang treatment group, lovastatin treatment group and atherosclerosis model group (8 in each group). blood lipids, blood rheology, malondialdehyde (MDA), total antioxidant capacity (t-AOc), and expression of aortic tissue factor (tF) and P65 were measured in each group. results: (1) Both Xuezhikang and lovastatin could reduce blood lipid levels, but there was no significant difference between the two groups; (2) Both Xuezhikang and lovastatin can improve the hemorheology of atherosclerotic rats, but the difference between the two groups is not signifcant; (3) Compared with lovastatin, Xuezhikang inhibited the expression of TF and P65 in aorta of rats with atherosclerosis; (4) Compared with lovastatin, the Xuezhikang group had lower MDA levels and higher T-AOC. Conclusion: Xuezhikang can improve blood lipid levels and hemorheology in rats with atherosclerosis. Compared with lovastatin, Xuezhikang has stronger effects on inhibiting oxidative stress and down-regulating the expression of tissue factor and P65.

References:

[1] Maoliang Zhang, Zhenwen Duan, Shenmeng Xie. Study on the active constituents of Xuezhikang[J]. Chinese Journal of New Drugs, 1998, 7(8):213-214. (in Chinese) [2] Xuezhikang adjusted blood lipids for coronary heart disease secondary prevention research collaboration group. Chinese coronary heart disease secondary prevention research[J]. Chinese Journal of Cardiology, 2005, 33 (2):109-115. (in Chinese) [3] Juan Zhao. Replication of rat atherosclerosis model[J]. Journal of Practical Medicine, 2008, 24(23):4139-4141. (in Chinese) [4] Lijuan Liu, Shiyao Ma, Sichun Liu. Pharmacological action and clinical evaluation of Xuezhikang[J]. Chinese Pharmacy, 2003, 14(3):184-186. (in Chinese) [5] Zheng J, Wang X, Li H, et al. Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins[J]. Clin Hemorheol Microcirc. 2009, 42(1):9-36. [6] S. Chien and L.A. Sung. Molecular basis of red cell membrane rheology[J]. Biorheology, 1990, 27:589-597. [7] Iwona Cicha, Yoji Suzuki, Norihiko Tateishi, et al rheological changes in human red blood cells under oxidative stress[J]. Pathophysiology 1999, 6:103-110. [8] Papaharalambus CA, Griendling KK. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury[J].Trends Cardiovasc Med, 2007, 17(2):48-54. [9] Görlach A. Redox regulation of the coagulation cascade[J]. Antioxid Redox Signal, 2005, 7:1398-1404. [10] Thiruvikraman SV, Guha A, Roboz J, et al. In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X[J]. Lab Invest, 1996, 75:451-461. [11] Mackman N. Regulation of the tissue factor gene[J]. Thromb Haemost, 1997, 78:747-754.