Comparison on Detection Results of Pathogen Nucleic Acids for Bronchoalveolar Lavage Fluid of Lung Infection Infants Between Uighur Nationality and Han Nationality

Source:
By:灵龙 鲁

DOI: https://doi.org/10.30564/jams.v3i1.1344

Abstract:

Objective: To analyze the detection results of pathogen nucleic acids for bronchoalveolar lavage fluid (BALF) of lung infection infants from Uighur nationality and Han nationality. Methods: A retrospective analysis was performed on the 318 infants with lung infection who were admitted to the hospital from April 2018 to April 2019. According to their nationality, they were divided into Uighur nationality group (190 cases) and Han nationality group (128 cases). The BALF specimens were collected to test pathogen nucleic acid. The distribution and positive rates of [respiratory syncytial virus (RSV), adenovirus (ADV), influenza virus A (IFA), influenza virus B (IFB), parainfluenza virus type 1 (PIV I), parainfluenza virus type 2 (PIV II), parainfluenza virus type 3 (PIV III)], bacteria (Streptococcus pneumoniae, Haemophilus influenzae, staphylococcus aureus, Pseudomonas aeruginosa, klebsiella pneumoniae), Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP) in both groups were observed and compared. Results: The virus detection for RSV, ADV and PIV III were on the top three in BALF from the children in both groups. The total positive rate of virus examination in Uighur nationality group was higher than that in Han nationality group (P<0.05). BALF in both groups was mainly on Streptococcus pneumoniae. The total positive rate of bacteria, MP and detection rate of chlamydia were higher in Uighur nationality group were higher than those in Han nationality group (P<0.05). Conclusion: The pathogen nucleic acid examination for bronchoalveolar lavage fluid in infants with lung viral infection is in the majority, mainly on RSV virus infection. The positive rates of virus, bacteria, MP and CP of children in Uighur nationality are high than those in Han nationality.

References:

[1] Sodhi K S,Bhatia A,Khandelwal N.Rapid lung magnetic resonance imaging in children with pulmonary infection[J].Pediatric Radiology,2017,47(6):1-2. [2] CHEN Yuhong, LUO Xueyi, ZHAO Xiaosu, et al. Clinical Value of PCR for Viral Detection of Bronchoalveolar Lavage Fluid in the Diagnosis and Treatment of Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation [J]. Chinese Journal of Hematology, 2017, 38(11):939. [3] Nadimpalli S,Foca M,Satwani P,et al.Diagnostic yield of bronchoalveolar lavage in immunocompromised children with malignant and non-malignant disorders[J].Pediatric Pulmonology,2017,52(6):820-826. [4] HUANG Xia, LIU Feng, LIANG Hui, et al. Bronchoscopy in the Diagnosis and Treatment of Children with Bronchiectasis [J]. Chinese Journal of Applied Clinical Pediatrics, 2017, 32(4): 289-291. [5] LE Jie. Gynecotokology [M]. 7th Edition. Beijing: People’s Medical Publishing House (PMPH), 2008: 94-95. [6] Respiratory Society of Chinese Medical Association. Chinese Expert Consensus for the Detection of Bronchoalveolar lavage Pathogens in Lung Infectious Diseases (2017 Edition) [J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2017, 40(08): 578. [7] Ozcan H N,Gormez A,Ozsurekci Y,et al.Rapid lung magnetic resonance imaging in children with pulmonary infection: reply to Sodhi et al[J].Pediatric Radiology,2017,47(6):766-766. [8] Suha R,Fahed H,Lea B,et al.Bronchoscopy and Bronchoalveolar Lavage in the Diagnosis and Management of Pulmonary Infections in Immunocompromised Children[J].Journal of Pediatric Hematology/Oncology, 2018,40(7):532-535. [9] De J V,Chang A B,Marchant J M.Comparison of bronchoscopy and bronchoalveolar lavage findings in three types of suppurative lung disease.[J].Pediatric Pulmonology,2018,53(4):467-474. [10] Tsai C M,Wong K S,Lee W J,et al.Diagnostic Value of Bronchoalveolar Lavage in Children with Nonresponding Community-Acquired Pneumonia.[J].Pediatrics & Neonatology,2017,58(5):430-436. [11] Bollmann B A,Seeliger B,Drick N,et al.Cellular analysis in bronchoalveolar lavage: inherent limitations of current standard procedure.[J].European Respiratory Journal,2017,49(6):1601844. [12] SHEN Wenna, WANG Lei, SUN Xinrong. Retrospective Analysis of Causes of Infant Wheezing [J]. Chinese Journal of Woman and Child Health Research, 2018, 29(5): 77-80. [13] GUO Wei, ZHANG Wenxin, QIU Chen, et al. Survey of Etiology of Children with Severe Pneumonia and Drug Resistance of Pathogens [J]. Chinese Journal of Nosocomiology, 2017, 27(21): 4998-5001. [14] LIU Lijun, LING Jizu, ZHAO Fuli. Analysis of the Etiological Characteristics of Mycoplasma Pneumoniae and Chlamydia Pneumoniae in Children with an Acute Respiratory Inflection and an Examination of their Clinical Significance [J]. Journal of Pathogen Biology, 2017, 12(2): 84-87+91. [15] DING Lin, JI Wei, ZHANG Xinxing. Pathogenic Analysis of 483 Cases of Severe Pneumonia in Children’s Hospital Affiliated to Suzhou University from 2012 to 2015 [J]. Chinese Journal of Practical Pediatrics, 2018, 33(6): 449-452.