Antioxidant Activity and Flavonoid Content of Matricaria Chamomilla Extracts from Different Populations of Iran

Updata:01-01-1970

Source:
By:Author(s)

DOI: https://doi.org/10.30564/jrb.v2i2.1909

Abstract:

Matricaria chamomilla is a valuable medicinal plant belonging to the Asteraceae family. Its medicinal and pharmaceutical impacts are correlated to major flavonoid compounds like apigenin. In this investigation, methanolic extracts of M. chamomilla inflorescence gathered from six natural populations were evaluated for their phytochemical content and antioxidant activity. The content of total flavonoid and phenol modified from 3.72 to 7.94 mg g-1 DW and 1.37 to 3.51 mg g-1 DW, respectively. Flavonoid compositions revealed significant differences among six populations, and the highest apigenin (1.27 % (w/w)) and apigenin-7-glucoside (0.86 %(w/w)) contents were recognized in MD populations, respectively. Both PCA and Pearson's correlation analyses revealed total phenol, flavonoid, apigenin and apigenin-7-glucoside were negatively correlated with the IC50 of DPPH activity and EC50 of reducing power. Altitude and precipitation indicated the positive and negative effects on phytochemical contents, respectively. These results can provide a theoretical basis for getting the targeted antioxidant phytochemicals of M. chamomilla for pharmaceutical and food industries, and also give a science for selection of the best population for cell culture and secondary metabolite production in future.

References:

[1] Pietta P.G. Flavonoids as antioxidants. Journal of Natural Products, 2000, 63(7): 1035-1042. [2] Nandita S., Rajini P.S. Free radical scavenging activity of an aqueous extract of potato peel. Food Chemistry, 2004, 85: 611-616. [3] Moyo M., Ndhlala A.R., Finnie J.F., Staden J.V. Phenolic composition, antioxidant and acetylcholinesterase inhibitory activities of Sclerocarya birrea and Harpephyllum caffrum (Anacardiaceae) extracts. Food Chemistry, 2010, 123: 69-76. [4] Ajila C.M., Rao J., Rao P. Characterization of bioactive compounds from raw and ripe MangiferaindicaL. peel extracts. Food and Chemical Toxicology, 2010, 48: 3406-3411. [5] Amarowicza R., Peggb R.B., Rahimi-moghaddam P., Barld B., Weilc J.A. Freeradical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies. Food Chemistry, 2004, 84: 551-562. [6] Sayadi V., Mehrabi A.A., Saidi M., Nourollahi K. In vitro culture and callus induction of chamomile (Matricariachamomilla L.) explants under different concentrations of plant growth regulators. International Journal of Biosciences, 2014, 4(10): 206-211. [7] Sebai H., Jabri M.A., Souli A., Rtibi K., Selmi S., Tebourbi O., El-Benna J., Sakly M.Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats. J Ethnopharmacol , 2014, 152(2): 327-32. [8] Zemestani M., Rafraf M., Asghari-Jafarabadi M. Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus. Nutrition, 2015, 14 (15): 00328-00327. [9] Patel D., Shukla S., Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise (review) Int J Oncol, 2007, 30: 233-245. [10] Ranpariya V.L., Parmar S.K., Sheth N.R., Chandrashekhar V.M. Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. Pharm Biol, 2011, 49: 696-701. [11] Coelho P.L.C., Amparo J.A.O., da Silva A.B., da Silva K.C., Braga-de-Souza S., Barbosa P.R., et al. Apigenin from croton betulaster Müll restores the immune profile of microglia against glioma cells. Phytother Res, 2019, 33: 3191-3202. [12] Haghi G., Hatami A., Safaei A., Mehran M. Analysis of phenolic compounds in Matricaria chamomilla and its extracts by UPLC-UV G. Res Pharm Sci, 2014, 9(1): 7-31. [13] Zhou M., Lin Y., Fang S., Liu Y., and Shang X. 2019. Phytochemical content and antioxidant activity in aqueous extracts of Cyclocarya paliurus leaves collected from different populations. PeerJ, 2019, 19(7): e6492. [14] Aryal S., Baniya M.K., Danekhu K., Kunwar P., Gurung R., Koirala N. 2019. Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from western nepal. Plants, 2019, 8(96). [15] Itidel C., Chokri M., Mohamed B., Yosr Z. Antioxidant activity, total phenolic and flavonoid content variation among Tunisian natural populations of Rhu tripartite (Ucria) Grande and Rhus pentaphylla Desf. Industrial Crops and Products, 2013, 51: 171-177. [16] Sati P., Pandey A., Rawat S., Rani A. Phytochemicals and antioxidants in leaf extracts of Ginkgo biloba with reference to location, seasonal variation and solvent system. Journal of Pharmacy Research, 2013, 7(9): 804-809. [17] D.Y. Zhang, M. Luo, W. Wang, C.J. Zhao, C.B. Gu, Y.G. Zu, Y.J. Fu, X.H. Yao, M.H. Duan. Variation of active constituents and antioxidant activity in pyrola (P. incarnata Fisch.) from different sites in Northeast China. Food Chemistry, 2013, 141(3): 2213-2219. [18] Pizzale L., Bortolomeazzi R., Vichi S., Überegger E., Conte L.S. Antioxidant activity of sage (Salvia officinalis and S. fruticosa) oregano (Origanum onites and O. indercedens) extracts related to their phenolic compund content. Journal Science Food Agricultural, 2002, 82: 1645-1651. [19] Vermerris W., Nicholson R. Isolation and identification of phenolic compounds. Phenolic Compound Biochemistry. Springer, Dordrecht, 2006: 151-191. [20] Hatamnia A.A., Abbaspour N., Darvishzadeh R. Antioxidant activity and phenolic profile of different parts of Bene (Pistacia atlantica subsp. kurdica) fruits. Food Chem, 2014, 145: 306-11. [21] Barreca D., Laganà G., Leuzzi U., Smeriglio A., Trombetta D., Bellocco E. Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio (Pistacia vera L., variety Bronte) Hulls.Food Chem, 2016, 196: 493-502. [22] Alothman M., Bhat R., Karim A.A. Antioxidant capacity and phenolic content of selected tropical fruits from Malaysia, extracted with different solvents. Food Chemistry, 2009, 115: 785-788. [23] Patro B.S., Bauri A.K., Mishra S., Chattopadhyay S. Antioxidant activity of Myristica malabarica extracts and their constituents. J Agri Food Chem, 2005, 53: 6912- 6918. [24] X. Xia, J. Cao, Y. Zheng, Q. Wang, J. Xiao. Flavonoid concentrations and bioactivity of flavonoid extracts from 19 species of ferns from China. Industrial Crops and Products, 2014, 58(1): 91-98. [25] Mamti G.E., Liang Y., Lu J. Expression of basic genes involved in Tea polyphenol synthesis in relation to accumulation of catechins and total tea polyphenols. J Sci Food Agric, 2006, 86: 459-464 [26] J. Chang, O.L. Lu, G. He. Regulation of polyphenols accumulation by combined expression silencing key enzymes of phenylpropanoid pathway. Acta Biochim Biophys Sin, 2009, 41: 123-130. [27] Ghasemi Pirbalouti A.G., Hashemi M., Taherian Ghahfarokhi F. Essential oil and chemical compositions of wild and cultivated Thymus daenensis Celak and Thymus vulgaris L. Ind Crop Prod, 2013, 48: 43- 48. [28] Pirkhezri M., Hassani M.E., Hadian J. Genetic diversity in different populations of Matricariachamomilla L. growing in douthwest of Iran, based on morphological and RAPD markers. Research Journal of Medicinal Plant, 2010, 4(1): 1-13. [29] AlDabbagh B., Elhaty IA., Elhaw M., Murali C., Mansoori A.A., Awad B., Amin A. Antioxidant and anticancer activities of chamomile (Matricaria recutita L.). BMC Research Notes, 2019, 12(1): 3.

Tags: