Expression of CDC20, TOP2A in Esophageal Phosphorus Carcinoma and Its Relationship with Survival of Esophageal Carcinoma

Source:
By:Yanjiao Liu, Longying He, Qian Zhang, Xinglong Zhang

DOI: https://doi.org/10.30564/jim.v9i2.2555

Abstract:

Objective: To study the expression of CDC20, TOP2A in esophageal squamous cell carcinoma and its relationship with survival of esophageal carcinoma. Methods: 65 patients with esophageal squamous cell carcinoma from January 2016 to June 2018 were selected by computer random selection. All patients were treated with radical operation. The CDC20, TOP2A expression of the patients was examined. At the same time, the relationship between 3-year survival rate and CDC20, TOP2A was analyzed by follow-up investigation. Results: the CDC20, TOP2A expression level of cancer tissue group was higher than that of adjacent tissue group and normal tissue group (P <0.05), and the CDC20, TOP2A expression level of adjacent tissue group was higher than that of normal tissue group (P <0.05). There was no significant difference in sex, age, tumor size, tumor location and CDC20, TOP2A expression level in patients with esophageal squamous cell carcinoma, P >0.05; there were differences between groups (P P >0.05) and positive proportion in TNM stage, lymphatic metastasis, invasion factor and CDC20, TOP2A expression level; there were differences in tumor differentiation, 5-year survival rate and CDC20, TOP2A expression level (P P >0.05), and showed inverse proportion relationship. Conclusion: metastasis, recurrence and prognosis of esophageal squamous cell carcinoma are related to the level of CDC20,
TOP2A expression. These two indexes can effectively evaluate the pathological situation of esophageal cancer and provide an important reference for the prognosis of esophageal squamous cell carcinoma patients.

References:

[1]Zi Wang, Xixi Zhang, Xiao Liu, et al. Effect and Prognostic Factors of Simultaneous Radiotherapy and Chemotherapy for Esophageal[J]. Cancer Chinese Journal of Radiological Oncology, 26(4): 400- 404. [2]Xingxiao Yang, Naiyi Zou, Qiaofang Li, et al. RNF2 and PCNA expression and clinical significance in esophageal squamous cell carcinoma Cancerous teratogenicity mutation, 30(04): 254-257. [3]Huijuan Zhang, Discipline Zhao, Xin Song. Relationship between PLCE1 protein expression and survival of patients in esophageal squamous cell carcinoma tissue[J]. Journal of Xinxiang Medical College, 2017000(012): 1068-1072. [4] Tao Liu, Tao Li. Advances in surgical and non-surgical treatment of esophageal cancer[J]. Medical Review, 2016, 22(3): 505-507.