Covid-19 and Immunity in the Elderly
Source: By:Hom Nath Chalise, Edwin Rosenberg
DOI: https://doi.org/10.30564/jgm.v2i1.2049
Abstract:Population ageing is an issue of worldwide importance. People are living longer due to advances in education, technology, medicine, food distribution, and public health. While the COVID-19 pandemic has significant global impacts, in many countries the elderlyface threats and challenges that are unique and disproportionately severe. One such threat is that aging results in a decline in immune function, meaning elderly bodies respond more slowly and less effectively to external threats like COVID-19. Responses at individual, family, community and societal levels should take into account the heightened vulnerability of older adults during this pandemic.
References:[1]Chalise HN. COVID-19 situation and challenges of Nepal. Asia Pac J Public Health, 2020: 1-2. DOI:https://doi.org/10.1177/1010539520932709 [2]Chalise HN. COVID-19 situation in Nepal. Arch PsychiatrMent Health. 2020, 4: 033-034. DOI: 10.29328/journal.apmh.1001015 [3]WHO. WHO announces COVID-19 outbreak a pandemic. WHO, Geneva, Switzerland, 2020. http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-apandemic [4]Worldometer. COVID-19 coronavirus pandemic, USA, 2020. https://www.worldometers.info/coronavirus/? [5]Chalise HN. South Asia is more vulnerable to COVID-19 pandemic. Arch Psychiatr Ment Health. 2020, 4: 046-047. DOI:https://doi.org/10.29328/journal.apmh.1001018 [6]Chalise HN. Aging: Basic Concept. Am J Biomed Sci& Res. 2019, 1(1). AJBSR.MS.ID.000503. DOI:https://doi.org/10.34297/AJBSR.2019.01.000503 [7]Chalise, H.N. and Rosenberg, E. Social and Health Status of Community-Dwelling Older Adults in Nepal. Advances in Aging Research, 2019, 8: 63-74. DOI:https://doi.org/10.4236/aar.2019.84005 [8]WHO. Statement - Older people are at highest risk from COVID-19, but all must act to prevent community spread, 2020. Accessed June 4, 2020 from http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/statements/statement-older-people-are-at-highest-riskfrom-covid-19,-but-all-must-act-to-prevent-community-spread [9]Population Reference Bureau. Countries with the oldest populations in the world, 2020. Accessed June 10, 2020 from https://www.prb.org/countries-with-the-oldest-populations [10]Development of novel coronavirus COVID-19 case fatality rate (CFR) in China from January 19 to May 28, 2020 https://www.statista.com/statistics/1108866/china-novel-coronavirus-covid19-case-fatality-rate-development [11]Medical News Today. The impact of the COVID-19 pandemic on older adults, Accessed at 4th June from https://www.medicalnewstoday.com/articles/the-impact-of-the-covid-19-pandemic-on-older-adults#Oldage-and-preexisting-health-conditions [12]https://www.worldometers.info/coronavirus/coronavirus-age-sex-demographics [13]Livingston E, Bucher K. Coronavirus Disease 2019 (COVID-19) in Italy. JAMA 2020. DOI:https://doi.org/10.1001/jama.2020.4344.32181795 [14]Chalise HN, Dhungana HN. Fears of COVID-19 catastrophe as Nepal reports death from new Coronavirus. J Phys Med RehabilDisabil, 2020, 6: 047. DOI:https://doi.org/10.24966/PMRD-8670/100047 [15]Sadighi Akha AA. Aging and the immune system: An overview. J Immunol Methods. 2018, 463: 21-26. DOI:https://doi.org/10.1016/j.jim.2018.08.005 [16]Johns Hopkins Medicine. The immune system. Accessed June 6, 2020 from https://www.hopkinsmedicine.org/health/conditions-and-diseases/the-immune-system#:~:text=The%20immune%20-system%20protects%20your,which%20you%20are%20born%20with [17]Márquez, E.J., Chung, C., Marches, R. et al. Sexual-dimorphism in human immune system aging. Nat Commun, 2020, 11: 751. DOI:https://doi.org/10.1038/s41467-020-14396-9 [18]STAT. What explains Covid-19’s lethality for the elderly? Scientists look to ‘twilight’ of the immune system. https://www.statnews.com/2020/03/30/what-explains-coronavirus-lethality-for-elderly [19] Montecino-Rodriguez, E., Berent-Maoz, B., Dorshkind, K. Causes, consequences, and reversal of immune system aging. The Journal of clinical investigation, 2013, 123(3): 958-965. DOI:https://doi.org/10.1172/JCI64096