Research Progress on the Relationship between Polymorphism and SLE of Vitamin D Metabolic Pathway Related Gene

Updata:01-01-1970

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By:Rui Han, Yuxuan Wang, Guanlu Li, Yiyu Cai, Zhilu Li, Yaqi Huang, Saijia Li, Pingping Yan

DOI: https://doi.org/10.30564/jhp.v3i1.2852

Abstract:
Vitamin D is a class of hormones necessary to maintain normal
physiological activities of the body. A large number of studies have shown
that vitamin D, as a fat-soluble vitamin, is not only related to calcium and
phosphorus metabolism, but also closely related to immune regulation,
humoral regulation, cell cycle and so on. Systemic Lupus erythema-Tosus
(SLE) is a specific autoimmune diffuse connective tissue disease that
causes tissue and organ damage under the joint action of multiple factors
such as environment and heredity. Among many factors, the vitamin D
metabolism pathway gene is particularly important for its influence. Some
literature has shown that the genetic polymorphism of vitamin D metabolic
pathway genes is correlated with SLE. Therefore, by referring to relevant
literature, this paper summarized the progress in the research on the
mechanism of genetic polymorphism of vitamin metabolism pathway genes
and the development of SLE.
References:

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