Primary Malignant Melanoma of Female Urethra: A Case Report and Review of Literature

Updata:01-01-1970

Source:
By:Author(s)

DOI: https://doi.org/10.30564/jor.v1i3.1975

Abstract:
We report a very rare case report of female diagnosed with primary ma
lignant melanoma. A 65 years old diabetic elderly postmenopausal female
presented with a history of intermittent blood spots on undergarments for
few days. Genital examination revealed a single, tan colored, soft chest
nut size and polypoidal non ulcerated mass lesion protruding through the
urethral meatus. Mass biopsy revealed poorly differentiated epithelial ma
lignancy and immuno-histological analysis revealed positive with HMB
45 and protein S-100 suggestive of melanoma. Metastatic work up for the
malignancy was negative. Complete urethrectomy with Mitrofanoff pro
cedure with inguinal lymph node dissection was performed. Histopatho
logical examination was suggestive of malignant melanoma of urethra.
Here we discuss the clinicopathological features and management option
possible in this scenario.
References:

[1]Stein BS, Kendall R. Malignant melanoma of the genitourinary tract. J Urol., 1984, 132: 859-68.

[2]Akbas A, Akman T, Erdem MR, Antar B, Kilicarslan I, Onol SY. Female urethral malignant melanoma with vesical invasion: a case report. Kaohsiung J Med Sci., 2010, 26: 96-8.

[3]Iversen K, Robins RE. Mucosal malignant melanomas. Am J Surg., 1980, 139: 660-4.

[4]Oliva E, Quinn TR, Amin MB, Eble JN, Epstein JI, Srigley JR, Young RH. Primary malignant melanoma of the urethra: a clinicopathologic analysis of 15 cases. Am J Surg Pathol., 2000, 24: 785-96.

[5]DiMarco DS, DiMarco CS, Zincke H, Webb MJ, Keeney GL, Bass S, Lightner DJ. Outcome of surgical treatment for primary malignant melanoma of the female urethra. J Urol., 2004, 171: 765-7.

[6]Kim CJ, Pak K, Hamaguchi A, Ishida A, Arai Y, Konishi T, et al. Primary malignant melanoma of the female urethra. Cancer, 1993, 71: 448-51.

[7]Reed CA. Melanosarcoma of the female urethra: Urethrectomy recovery. Am J Obstet Gynecol., 1896, 34: 864-72.

[8]Seetharamu N, Ott PA, Pavlick AC. Mucosal melanomas: a casebased review of the literature. Oncologist., 2010, 15: 772-81.

[9]Oliva E, Quinn TR, Amin MB, Eble JN, Epstein JI, Srigley JR, et al. Primary malignant melanoma of the urethra: A clinicopathologic analysis of 15 cases. Am J Surg Pathol., 2000, 24: 785-96.

[10]Papeš D, Altarac S. Melanoma of the female urethra. Medical Oncology. 2013, 30(1): 329.

[11]Filipkowski LA, Barker MA, Karram MM. Primary genitourinary melanoma presenting as voiding dysfunction. Int Urogynecol J Pelvic Floor Dysfunct., 2009, 20: 1141-3.

[12]Alvarez Kindelan J, Merchan Garcia JA, Olmo Cerezo I, Moreno Rodriguez MM, Gonzalez Arlanzon MM. Primary malignant melanoma of the female urethra. Report of a case. Actas Urol Esp., 2000, 24: 488-90.

[13]L.J. Markovi Pua, A. Relji, B. Kru lin, Primarni maligni melanom enske uretre, Lije Vjesn, 1999, 121: 98-99.

[14]Sugiyama VE, Chan JK, Kapp DS. Management of melanomas of the female genital tract. Curr Opin Oncol., 2008, 20: 565-9.

[15]Kim CJ, Pak K, Hamaguchi A, Ishida A, Arai Y, Konishi T, et al. Primary malignant melanoma of the female urethra. Cancer, 1993, 71: 448-51.

[16]Rikaniadis N, Konstadoulakis MM, Kymionis GD, Tsibloulis B, Peveretos P, Karakousis CP. Long-term survival of a female patient with primary malignant melanoma of the urethra. Eur J Surg Oncol., 1998, 24(6): 607-8.

[17]Katz JI, Grabstald H. Primary malignant melanoma of the female urethra. J Urol., 1976, 116: 454-7.

[18]Dasgupta T, Grabstald H. Melanoma of the genitourinary tract. J Urol., 1965, 93: 607-14.

[19]Mayer R, Fowler JE Jr, Clayton M. Localized urethral cancer in women. Cancer, 1987, 60: 1548-51.

[20]Sheffield MV, Yee H, Dorvault CC, Weilbaecher KN, Eltoum IA, Siegal GP, et al. Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations. Am J Clin Pathol., 2002, 118: 930-6.

[21] Kelley MC, Ollila DW, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for melanoma. Semin Surg Oncol., 1998, 14: 283-90.

Tags: