Updata:01-01-1970
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DOI: https://doi.org/10.30564/jor.v2i2.2549
Abstract:
Objective: to study the expression and clinical significance CDC20,TOP2A, NEK2 esophageal squamous cell carcinoma. Methods: Toselect 70 patients with esophageal squamous cell carcinoma, Between August 2018 - August 2020, All intraoperative pathological specimens,A group -35 cases), Cancer tissue, B group, adjacent tissues), two groups of CDC20, TOP2A, NEK 2 expression were detected and analyzed by immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction -RT-PcR) assay.Results: the values of CDC20,TOP2A, NEK2 expression level in A group were significantly higher than
those in B group -P<0.05). The expression level CDC20, TOP2A, NEK2
esophageal squamous cell carcinoma was positively correlated with TNM
stage and lymphatic metastasis, and negatively correlated with tumor
differentiation. Conclusion: CDC20, TOP2A, NEK2 high expression level
directly affects the metastasis, recurrence and prognosis of esophageal
squamous cell carcinoma. The combination of three indexes can accurately
evaluate the pathological status of patients with esophageal squamous cell
carcinoma and help to judge the prognosis of patients accurately
References:
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