Urticaria Successfully Treated with Mindfulness and Nutraceutical Supplements
Source: By:Jozélio Freire de Carvalho
DOI: https://doi.org/10.30564/jim.v10i1.2992
Abstract:The study is to describe a patient with urticarial lesions which was successfully treated with mindfulness and nutraceuticals. A 20-year-old female patient with an unmarked past medical history presented with diffuse pruritic urticarial lesions associated with breathless and severe fatigue, lasting for 5 months. The lesions covered all body, except palms and plants. Hospitalized for three days, she received dexamethasone, promethazine, and subcutaneous adrenalin and discharged with fexofenadine, prednisone, and ranitidine. Mindfulness and relaxation practice were instructed and some nutraceuticals. After two months, she returned asymptomatic, without any new episodes of urticaria or fatigue. Most of the chronic urticaria patients are treated with antihistamines and/or steroids. This case illustrates an alternative holistic approach, combining mindfulness and relaxation practices with nutraceuticals. This alternative therapeutical strategy should be explored by back to back comparison to the conventional pharmaceutical approach.
References:[1] Morelli V, Calmet E, Jhingade V. Alternative therapies for common dermatologic disorders, part 1. Prim Care. 2010;37(2):269-283. [2] Antia C, Baquerizo K, Korman A, Alikhan A, Bernstein JA. Urticaria: A comprehensive review:Treatment of chronic urticaria, special populations, and disease outcomes. J Am Acad Dermatol.2018;79(4):617-633. [3] Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893-89. [4] Morelli V, Calmet E, Jhingade V. Alternative therapies for common dermatologic disorders, part 1. Prim Care. 2010;37(2):269-283. [5] Tuchinda P, Kulthanan K, Chularojanamontri L,Arunkajohnsak S, Sriussadaporn S. Relationship between vitamin D and chronic spontaneous urticaria: a systematic review. Clin Transl Allergy. 2018;8:51. [6] Rorie A, Poole JA. Vitamin D supplementation: a potential booster for urticaria therapy. Expert Rev Clin Immunol. 2014;10(10):1269-1271. [7] Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A.Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: A prospective case-control study [retracted in: Dermatoendocrinol. 2018 Nov 2;10(1):e1512251].Dermatoendocrinol. 2014;8(1):e983685. [8] Mureşan D, Oană A, Nicolae I, et al. Investigations of magnesium, histamine and immunoglobulins dynamics in acute urticaria. Arch Roum Pathol Exp Microbiol. 1990;49(1):31-35. [9] Bansal CJ, Bansal AS. Stress, pseudoallergens, autoimmunity, infection, and inflammation in chronic spontaneous urticaria. Allergy Asthma Clin Immunol.2019;15:56. [10] Becker A, Felgentreff F, Schröder H, Meier B, Brattström A. The anxiolytic effects of a Valerian extract is based on valerenic acid. BMC Complement Altern Med. 2014;14:267. [11] Abdala-Valencia H, Berdnikovs S, McCary CA, et al.Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan. Am J Physiol Lung Cell Mol Physiol. 2012;303(8):L642-L660. [12] Rezazadeh A, Shahabi S, Bagheri M, Nabizadeh E,Jazani NH. The protective effect of Lactobacillus and Bifidobacterium as the gut microbiota members against chronic urticaria. Int Immunopharmacol.2018;59:168-173. [13] Anhê FF, Varin TV, Le Barz M, et al. Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts. Curr Obes Rep. 2015;4(4):389-400. [14] Lyu Y, Wu L, Wang F, Shen X, Lin D. Carotenoid supplementation and retinoic acid in immunoglobulin A regulation of the gut microbiota dysbiosis. Exp Biol Med (Maywood). 2018;243(7):613-620. [15] Serrano-Villar S, Vázquez-Castellanos JF, Vallejo A,et al. The effects of prebiotics on microbial dysbiosis,butyrate production, and immunity in HIV-infected subjects. Mucosal Immunol. 2017;10(5):1279-1293. [16] Kobayashi S. Investigation of the roles of the substances in serum lipids and their constitutive fatty acids in chronic urticaria. J Dermatol. 1989;16(3):196-206. [17] Kiecolt-Glaser JK, Glaser R, Christian LM. Omega-3 fatty acids and stress-induced immune dysregulation:implications for wound healing [published correction appears in Mil Med. 2016 Sep;181(9):1165]. Mil Med. 2014;179(11 Suppl):129-133. [18] Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem. 1996;25:189-213. [19] Barbosa F, Freitas J, Barbosa A. Chronic idiopathic urticaria and anxiety symptoms. J Health Psychol.2011 Oct;16(7):1038-47. [20] Tzur Bitan D, Berzin D, Cohen A. The association of chronic spontaneous urticaria (CSU) with anxiety and depression: a nationwide cohort study. Arch Dermatol Res. 2021 Jan;313(1):33-39.