Signaling Pathways Associated with Cancer Stem Cells Play a Significant Role in Immunotherapy Resistance
Article: The different signaling pathways associated with CSCs may play a vital role in the immune resistance. The specific mechanisms inducing the immune resistance include—
the recruitment of immunosuppressive cells, especially MDSCs and Treg cells, to the TME; enhancement of CSC properties, especially the EMT; the regulation of PD-L1
Distributed under creative commons license 4.0 5 expression on the tumor or CSC surface to inhibit CD8+ T cell cytotoxicity and even the direct loss of CD8+ T cells (Figure 2).
Cleck out the full article(OA): https://ojs.bilpublishing.com/index.php/jor/article/view/1409
If you want to join us please email me：jor@bilpunlishing.com
